⚠️ Mechanism
Glycyrrhizin in licorice inhibits 11β-HSD, causing cortisol to activate mineralocorticoid receptors, increasing sodium retention and potassium excretion.
📋 Effect
Hypertension; hypokalemia; counteracts antihypertensive drugs
💊 Management
Avoid licorice supplements with antihypertensives. Monitor blood pressure and potassium.
Plain Language Summary
This combination can be risky for your health. Licorice can cause your body to hold onto extra salt and lose potassium, which may raise your blood pressure and make your medication less effective.
Source
Farese RV Jr et al. Endocrinol Metab Clin North Am 1991; FDA licorice warnings
Supporting Research
Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.