⚠️ Mechanism
Kava may have weak MAO-inhibiting properties; combined with SSRIs may increase serotonin levels.
📋 Effect
Possible serotonin syndrome
💊 Management
Avoid combination. Use caution with any serotonergic medication.
Plain Language Summary
This combination is potentially dangerous. Taking Kava with SSRIs may cause serotonin levels in your body to rise too high, which can lead to a serious condition called serotonin syndrome.
Source
Mischoulon D, Fava M. J Clin Psychiatry 2002
Supporting Research
Kava in generalized anxiety disorder: three placebo-controlled trials
Explanatory attributions of anxiety and recovery in a study of kava
Kava-Kava administration reduces anxiety in perimenopausal women
Kava treatment in patients with anxiety
Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.