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Kava × Oral Contraceptives
MODERATE INTERACTION
⚠️ Mechanism
Kava is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk because Kava can slow down the way your body processes oral contraceptives. This may lead to higher levels of the medication in your bloodstream, which could increase the chance of experiencing side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Kava in generalized anxiety disorder: three placebo-controlled trials
PMID:16877894
2006
Explanatory attributions of anxiety and recovery in a study of kava
PMID:15253862
2004
Kava-Kava administration reduces anxiety in perimenopausal women
PMID:12590005
2003
Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines
PMID:11605083
2001
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.