⚠️ Mechanism
Kava is a weak inhibitor of CYP1A2, which decreases metabolism of CYP1A2 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of melatonin (melatonin), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of melatonin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk of increasing side effects. Kava can slow down the way your body breaks down melatonin, which may cause higher levels of melatonin to build up in your system.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Kava in generalized anxiety disorder: three placebo-controlled trials
Explanatory attributions of anxiety and recovery in a study of kava
Kava-Kava administration reduces anxiety in perimenopausal women
Kava treatment in patients with anxiety
Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.