⚠️ Mechanism
Iron reduces penicillamine absorption by forming insoluble complexes.
📋 Effect
Reduced penicillamine efficacy
💊 Management
Separate doses by at least 2 hours.
Plain Language Summary
This interaction is considered moderate because iron can prevent your body from absorbing penicillamine properly. When taken together, the two substances bind together, which may make the medication less effective. The data indicates that doses should be separated by at least 2 hours.
Source
Harkness JA, Blake DR. BMJ 1982
Supporting Research
Serum or plasma ferritin concentration as an index of iron deficiency and overload
Non-invasive diagnostic tests for Helicobacter pylori infection
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations
Fortification of condiments and seasonings with iron for preventing anaemia and improving health
Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement.
Parenteral versus oral iron therapy for adults and children with chronic kidney disease
Wheat flour fortification with iron for reducing anaemia and improving iron status in populations
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.