⚠️ Mechanism
Iron chelates fluoroquinolone antibiotics, reducing absorption.
📋 Effect
Reduced antibiotic absorption and efficacy
💊 Management
Separate doses by at least 2 hours before or 6 hours after antibiotic.
Plain Language Summary
This combination can be problematic because iron can prevent your body from absorbing the antibiotic properly. When taken together, the iron binds to the medicine, which may make the treatment less effective. The data suggests separating these doses by at least 2 hours before or 6 hours after the antibiotic.
Source
FDA fluoroquinolone labeling
Supporting Research
Serum or plasma ferritin concentration as an index of iron deficiency and overload
Non-invasive diagnostic tests for Helicobacter pylori infection
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations
Fortification of condiments and seasonings with iron for preventing anaemia and improving health
Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement.
Parenteral versus oral iron therapy for adults and children with chronic kidney disease
Wheat flour fortification with iron for reducing anaemia and improving iron status in populations
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.