⚠️ Mechanism
Ginseng may reduce warfarin efficacy, possibly through CYP enzyme induction or ginsenoside effects on clotting.
📋 Effect
Reduced anticoagulant effect; decreased INR
💊 Management
Monitor INR closely. Avoid ginseng supplements if possible.
Plain Language Summary
This combination requires caution because ginseng may interfere with how warfarin works. It can make the medication less effective at thinning your blood, which could increase your risk of developing blood clots.
Source
Yuan CS et al. Ann Intern Med 2004; Jiang X et al. Eur J Clin Pharmacol 2004
Supporting Research
Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis
Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis
Dose-response and temporal ergogenic effects of ginseng supplementation in athletes and active participants: A systematic review and meta-analysis
Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials
[Dan'e-fukang soft extract for dysmenorrhea: a meta-analysis]
Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis
The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.