Ginseng × Ssri
MINOR
Possible Evidence
Mechanism
Ginseng may have weak MAO-inhibiting properties; theoretical risk of serotonin syndrome with SSRIs.
Effect
Possible additive serotonergic effect (rare)
Management
Generally safe at typical doses. Report any agitation or confusion.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination is generally considered safe at typical doses. However, there is a small risk that ginseng could increase serotonin levels when taken with an SSRI, which could rarely lead to symptoms such as agitation or confusion.
Source
Mischoulon D, Fava M. J Clin Psychiatry 2002
Research
Supporting Research
Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis
PMID:16369479
2006
Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis
Dose-response and temporal ergogenic effects of ginseng supplementation in athletes and active participants: A systematic review and meta-analysis
Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials
[Dan'e-fukang soft extract for dysmenorrhea: a meta-analysis]
PMID:25187464
2014
Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis
The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.