⚠️ Mechanism
Ginseng is a weak inhibitor of CYP2C9, which decreases metabolism of CYP2C9 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of ibuprofen (nsaids), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of ibuprofen. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may be moderately unsafe because it can increase the risk of side effects. Ginseng can slow down the way your body processes drugs like ibuprofen, which may cause the medication to build up to higher levels in your system.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis
Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis
Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis
Dose-response and temporal ergogenic effects of ginseng supplementation in athletes and active participants: A systematic review and meta-analysis
Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials
[Dan'e-fukang soft extract for dysmenorrhea: a meta-analysis]
Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis
The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.