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Ginkgo × Trazodone

MODERATE INTERACTION — Possible Evidence

⚠️ Mechanism

Ginkgo combined with trazodone may cause excessive sedation or CNS effects.

📋 Effect

Excessive CNS depression; coma reported in one case

💊 Management

Avoid combination. Use alternative herbal supplement.

Plain Language Summary

This combination is considered dangerous. Taking Ginkgo with trazodone may cause extreme sleepiness or severe depression of the central nervous system, and one case of coma has been reported.

Source

Gurley BJ et al. Ther Drug Monit 2005 (case report)

Supporting Research

Ginkgo biloba for cognitive impairment and dementia PMID:41641880 DOI:10.1002/14651858.CD013661.pub2 2026
Ginkgo biloba for cognitive impairment and dementia PMID:19160216 DOI:10.1002/14651858.CD003120.pub3 2009
Ginkgo biloba for tinnitus PMID:23543524 DOI:10.1002/14651858.CD003852.pub3 2013
Ginkgo biloba for tinnitus PMID:36383762 DOI:10.1002/14651858.CD013514.pub2 2022
Ginkgo biloba for intermittent claudication PMID:23744597 DOI:10.1002/14651858.CD006888.pub3 2013
The Comparative Efficacy of Multiple Interventions for Mild Cognitive Impairment in Alzheimer's Disease: A Bayesian Network Meta-Analysis PMID:32581760 DOI:10.3389/fnagi.2020.00121 2020
Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis PMID:41678913 DOI:10.1016/j.phymed.2026.157915 2026
Ginkgo biloba for intermittent claudication PMID:19370657 DOI:10.1002/14651858.CD006888.pub2 2009
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.