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Ginkgo × Ssri

MODERATE INTERACTION — Possible Evidence

⚠️ Mechanism

Ginkgo may have weak MAO-inhibiting properties; combined with SSRIs may increase serotonin levels.

📋 Effect

Possible serotonin syndrome (rare but reported)

💊 Management

Use caution with SSRIs. Report any symptoms of agitation, confusion, or tremor.

Plain Language Summary

This combination should be approached with caution. Taking Ginkgo with an SSRI may cause serotonin levels in your body to rise, which could potentially lead to a rare condition called serotonin syndrome.

Source

Spinella M. J Clin Psychopharmacol 2001; Mischoulon D, Fava M. J Clin Psychiatry 2002

Supporting Research

Ginkgo biloba for cognitive impairment and dementia PMID:41641880 DOI:10.1002/14651858.CD013661.pub2 2026
Ginkgo biloba for cognitive impairment and dementia PMID:19160216 DOI:10.1002/14651858.CD003120.pub3 2009
Ginkgo biloba for tinnitus PMID:23543524 DOI:10.1002/14651858.CD003852.pub3 2013
Ginkgo biloba for tinnitus PMID:36383762 DOI:10.1002/14651858.CD013514.pub2 2022
Ginkgo biloba for intermittent claudication PMID:23744597 DOI:10.1002/14651858.CD006888.pub3 2013
The Comparative Efficacy of Multiple Interventions for Mild Cognitive Impairment in Alzheimer's Disease: A Bayesian Network Meta-Analysis PMID:32581760 DOI:10.3389/fnagi.2020.00121 2020
Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis PMID:41678913 DOI:10.1016/j.phymed.2026.157915 2026
Ginkgo biloba for intermittent claudication PMID:19370657 DOI:10.1002/14651858.CD006888.pub2 2009
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.