⚠️ Mechanism
Ginkgo is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk because Ginkgo can prevent your body from breaking down oral contraceptives as quickly as usual. This may lead to higher levels of the medication in your system, which could increase the risk of side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)