⚠️ Mechanism
Ginkgo is a weak inducer of CYP1A2, which increases metabolism of CYP1A2 substrates, potentially reducing their plasma concentrations and therapeutic efficacy.
📋 Effect
Reduced plasma levels of caffeine (caffeine), potentially leading to therapeutic failure.
💊 Management
Monitor for reduced efficacy of caffeine. Dose adjustment may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may cause a moderate interaction that reduces the effectiveness of caffeine. Ginkgo can cause your body to break down caffeine more quickly, which may lead to lower levels of caffeine in your system.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Ginkgo biloba for cognitive impairment and dementia
Ginkgo biloba for cognitive impairment and dementia
Ginkgo biloba for tinnitus
Ginkgo biloba for tinnitus
Ginkgo biloba for intermittent claudication
The Comparative Efficacy of Multiple Interventions for Mild Cognitive Impairment in Alzheimer's Disease: A Bayesian Network Meta-Analysis
Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis
Ginkgo biloba for intermittent claudication
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.