⚠️ Mechanism
Garlic supplements decrease saquinavir plasma concentrations via CYP3A4 induction.
📋 Effect
Reduced antiretroviral efficacy
💊 Management
Avoid garlic supplements with protease inhibitors. Dietary garlic is safe.
Plain Language Summary
Taking garlic supplements with saquinavir can be problematic because they may lower the amount of medicine in your body. This reduction can make the medication less effective at fighting the virus.
Source
Gallicano K et al. Clin Pharmacol Ther 2003
Supporting Research
Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials
Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis
Garlic for the common cold
Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effects of seasoning on the formation of heterocyclic amines and polycyclic aromatic hydrocarbons in meats: A meta-analysis
A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia
Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials
Garlic for the common cold
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.