⚠️ Mechanism
Garlic is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of clarithromycin (antibiotics), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of clarithromycin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may be moderately risky because garlic can cause certain antibiotics to build up in your body. This increase in medication levels could lead to a higher risk of experiencing side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Garlic supplementation for the treatment of chronic liver disease: a meta-analysis of randomized controlled trials
Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis
Garlic for the common cold
Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effects of seasoning on the formation of heterocyclic amines and polycyclic aromatic hydrocarbons in meats: A meta-analysis
A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia
Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials
Garlic for the common cold
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.