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Do not combine without physician supervision. If you are already taking both Cranberry and GI Prokinetics, contact your healthcare provider today. Do not stop any medication without professional guidance.

Cranberry × GI Prokinetics

CRITICAL Cyp-Inferred Evidence

Mechanism

Cranberry is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination is dangerous because cranberry can slow down how your body processes this medication. This may cause the drug to build up to higher levels in your bloodstream, increasing the risk of serious side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Study of Oral Anthocyanins on Insulin Resistance
2010
The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans
2014
Adverse Event Profile: Cranberry
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.