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Chromium Ɨ Levothyroxine

MINOR INTERACTION — Possible Evidence

āš ļø Mechanism

Chromium picolinate may reduce levothyroxine absorption.

šŸ“‹ Effect

Possible reduced levothyroxine absorption

šŸ’Š Management

Separate doses by at least 2-4 hours.

Plain Language Summary

This is a minor interaction. Chromium may reduce the amount of levothyroxine your body absorbs. Separating these doses by 2 to 4 hours is a way to manage this effect.

Source

Anon. Drugdex Drug Evaluations 2004

Supporting Research

1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis PMID:26825231 DOI:10.1016/S0140-6736(15)01039-9 2016
Interventions for preventing weight gain after smoking cessation PMID:34611902 DOI:10.1002/14651858.CD006219.pub4 2021
Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence PMID:39863768 DOI:10.1038/s41370-025-00744-8 2025
Effects of cobalt-chromium everolimus eluting stents or bare metal stent on fatal and non-fatal cardiovascular events: patient level meta-analysis PMID:25378023 DOI:10.1136/bmj.g6427 2014
Chromium picolinate supplementation for overweight or obese adults PMID:24293292 DOI:10.1002/14651858.CD010063.pub2 2013
Metalloestrogens exposure and risk of gestational diabetes mellitus: Evidence emerging from the systematic review and meta-analysis PMID:38307186 DOI:10.1016/j.envres.2024.118321 2024
Trace elements in schizophrenia: a systematic review and meta-analysis of 39 studies (N = 5151 participants) PMID:31800085 DOI:10.1093/nutrit/nuz059 2020
A meta-analysis of heavy metals pollution in farmland and urban soils in China over the past 20 years PMID:33334517 DOI:10.1016/j.jes.2020.08.013 2021
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.