⚠️ Mechanism
Caffeine and theophylline are both methylxanthines; combined use has additive stimulant and bronchodilatory effects.
📋 Effect
Excessive CNS stimulation; tachycardia; increased theophylline toxicity risk
💊 Management
Limit caffeine intake with theophylline. Monitor theophylline levels.
Plain Language Summary
This combination can be risky because both substances act as stimulants in the body. Using them together may cause excessive stimulation, a fast heartbeat, and an increased risk of theophylline toxicity.
Source
FDA theophylline labeling; Becking GJ et al. Clin Pharmacol Ther 1982
Supporting Research
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Effects of caffeine chewing gum supplementation on exercise performance: A systematic review and meta-analysis
Genetic susceptibility to caffeine intake and metabolism: a systematic review
Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis
Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes
Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis
Effect of Acute Caffeine Intake on Fat Oxidation Rate during Fed-State Exercise: A Systematic Review and Meta-Analysis
The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.