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MSM & Glucosamine

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Glucosamine and MSM are commonly used to support joint health, though research evidence for their efficacy remains mixed to moderate. Potassium and calcium provide essential mineral support for cellular function and bone maintenance. These ingredients are generally well-tolerated and maintain a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for MSM & Glucosamine
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Potassium
87 mg (3% DV)
Calcium
65 mg (7% DV)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
MSM
500 mg
Market median: 1000.0mg (2 products)

Other Ingredients

Stearic Acid Cellulose Silica Cellulose Gum Magnesium Stearate Methylcellulose Glycerin Carnauba Wax
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 tablet, three times daily, with a meal.

Warnings & Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs. Do not use if you are pregnant or lactating.

KEEP OUT OF REACH OF CHILDREN.

Contains Crustacean Shellfish (Crab & Shrimp).

Formulation Notes

Contains Crustacean Shellfish (Crab & Shrimp).

NO Milk, Egg, Fish, Tree Nuts, Wheat, Peanuts, Soybeans, Yeast, Corn, Artificial Colors or Flavors, Added Sugar, Starch or Preservatives

Additional Information

MSM (Methylsulfonylmethane) and Glucosamine Sulfate are the subject of research on connective tissue and joint health. MSM is a compound containing sulfur, which is important in promoting joint flexibility, while Glucosamine has been shown to regenerate cartilage for greater joint comfort.

STORE IN A COOL, DRY PLACE.

ITEM: 16128 F: 3000107 L: 2004414-15161

• Clinically Tested Ingredients to Promote Healthy Joints and Cartilage • Supports Joint Comfort • Double Strength

Metadata

Product Details

UPC / SKU0 47469 16128 6
DSLD Entry Date2016-01-25
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
BrandNatrol
DSLD ID55571
Data Updated2026-04-11
Research

Research Evidence

39
Research Sources
50
Avg Quality
20
Rct
9
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Regulatory Source
1
Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023 PubMed DOI
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009 DOI
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
View all evidence for Glucosamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.