Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients

Kinnunen et al., 1993 | Pharmacology | Rct

Citation

Kinnunen O, Winblad I, ... Salokannel J. Safety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patients. Pharmacology. 1993-Oct;47 Suppl 1:253-5

Abstract

Thirty geriatric long-stay patients aged 65-94 years (mean 81.8) participated in the trial the aim of which was to examine bulk laxative plus senna (Agiolax) in the treatment of chronic constipation using lactulose (Levolac) as a reference medicine. Bulk laxative plus senna (daily doses 14.8 g) produced more frequent (p < 0.05) bowel habits (4.5 vs. 2.2-1.9/week) than lactulose (daily doses 20.1 g). Both laxatives proved to be safe to use. Our study indicated bulk laxative plus senna to be more efficient in treating constipation in geriatric long-stay patients.

Key Findings

Our study indicated bulk laxative plus senna to be more efficient in treating constipation in geriatric long-stay patients.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	aged 65-94
Condition	See abstract

MeSH Terms

Aged
Aged, 80 and over
Cathartics
Chronic Disease
Constipation
Drug Combinations
Female
Gastric Emptying
Gastrointestinal Motility
Humans
Lactulose
Male
Plant Extracts
Plantago
Senna Extract

Evidence Classification

Level: Rct
Publication Types: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial
Vertical: senna

Provenance

PMID: 8234438
DOI: (not available)
PMCID: Not in PMC
Verified: 2026-04-12 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-12