Bioactives and exercise synergize to modulate AMPK and inflammation

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#humans #amp-activated-protein-kinases #animals #inflammation #exercise

Bioactives and exercise synergize to modulate AMPK and inflammation

Sheng et al., 2025 | Front Immunol | Systematic Review

Citation

Sheng ZhaoHui, Luo Quan, ... Yang Xingjie. Bioactives and exercise synergize to modulate AMPK and inflammation. Front Immunol. 2025;16:1670379. doi:10.3389/fimmu.2025.1670379

Abstract

AMP-activated protein kinase (AMPK) regulates energy homeostasis and immune responses, making it a key target for immunometabolic disorders like obesity, insulin resistance, and neurodegenerative diseases. This review explores the synergistic effects of plant-derived bioactives (e.g., quercetin, resveratrol, curcumin) and exercise on AMPK signaling, focusing on metabolic and immunological outcomes. A systematic search (PubMed, Scopus, Web of Science, up to June 2025) identified 14 preclinical studies showing that combined interventions enhance AMPK phosphorylation, mitochondrial biogenesis, glucose uptake, and lipid oxidation while reducing pro-inflammatory cytokines (e.g., TNF-α, IL-6) and NF-κB signaling via SIRT1/PGC-1α/Nrf2 pathways. Tissue-specific effects in skeletal muscle, heart, brain, liver, and adipose tissue highlight their therapeutic potential. Variability in study designs and limited clinical data necessitate further mechanistic studies, particularly on epigenetic regulation (e.g., histone acetylation, miRNAs), to optimize personalized non-pharmacological strategies.

Key Findings

Variability in study designs and limited clinical data necessitate further mechanistic studies, particularly on epigenetic regulation (e.g., histone acetylation, miRNAs), to optimize personalized non-pharmacological strategies.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • AMP-Activated Protein Kinases
  • Animals
  • Inflammation
  • Exercise
  • Signal Transduction
  • Phytochemicals

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09