The relationship between fat-soluble vitamins and uterine fibroids: a systematic review

source extracted confidence: high 2026-04-09
#humans #leiomyoma #female #vitamins #vitamin-d

The relationship between fat-soluble vitamins and uterine fibroids: a systematic review

Dashti et al., 2025 | BMC Womens Health | Systematic Review

Citation

Dashti Sareh, Jalal Marvi Fatemeh, ... Fathi Najafi Tahereh. The relationship between fat-soluble vitamins and uterine fibroids: a systematic review. BMC Womens Health. 2025-Nov-29;26(1):28. doi:10.1186/s12905-025-04189-x

Abstract

BACKGROUND: Uterine fibroids (UF) is a common gynecology tumor that in some cases may require hysterectomy. It is hypothesized that deficiency in fat-soluble vitamins might be a risk factor for UF. The aim of this systematic review was to evaluate the relationship between fat-soluble vitamins and UFs. METHODS: This systematic review was conducted on published articles in PubMed and Web of Science till Feb 2024 using a comprehensive search strategy. RESULTS: Of the initial 9161 identified articles, 31 (overall population of 55189 participants), including 17 case-control studies, 6 clinical trials, four cross-sectional studies, three cohort studies, and one Mendelian epidemiological study were reviewed. Majority of the studies evaluated the relationship between serum vitamin D and UF incidence and size. None of the reviewed studies evaluated the relationship between vitamin K and UF. CONCLUSIONS: Vitamin D supplementation and intake of animal sources of vitamin A could reduce UF size. There is not enough evidence regarding the effect of vitamin K and E on UF size.

Key Findings

Of the initial 9161 identified articles, 31 (overall population of 55189 participants), including 17 case-control studies, 6 clinical trials, four cross-sectional studies, three cohort studies, and one Mendelian epidemiological study were reviewed. Majority of the studies evaluated the relationship between serum vitamin D and UF incidence and size. None of the reviewed studies evaluated the relationship between vitamin K and UF.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 55189
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Leiomyoma
  • Female
  • Vitamins
  • Vitamin D
  • Uterine Neoplasms
  • Dietary Supplements
  • Vitamin A
  • Vitamin K
  • Vitamin E
  • Risk Factors

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09