The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses

source extracted confidence: high 2026-04-09
#humans #resveratrol #obesity #body-mass-index #waist-circumference

The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses

Abu-Zaid et al., 2025 | Eat Weight Disord | Systematic Review

Citation

Abu-Zaid Ahmed, Saleh Saleh A K, ... Alharran Abdullah M. The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses. Eat Weight Disord. 2025-Nov-29;30(1):92. doi:10.1007/s40519-025-01800-w

Abstract

OBJECTIVE: Despite several studies assessing the impact of resveratrol on obesity indices, previous meta-analyses show conflicting results. Therefore, we conducted this critical umbrella review of interventional meta-analyses on the effect of resveratrol supplementation on body mass index (BMI), body weight (BW), waist circumference (WC), and body fat. METHODS: Searches were conducted across multiple databases to identify all relevant meta-analyses up to September 30th, 2025. Reported pooled effect sizes (ESs) and 95% confidence intervals (CIs) were extracted from each included study and synthesized using a random-effects model. Methodological quality was assessed using the AMSTAR 2 tool. RESULTS: Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: - 0.18 kg, 95% CI - 0.32 to - 0.03, p = 0.02), BMI (ES: - 0.14 kg/m2, 95% CI - 0.2 to - 0.08, p < 0.001), WC (ES - 0.43 cm, 95% CI - 0.64 to - 0.22, p < 0.001), and body fat (ES: - 0.3 kg, 95% CI - 0.48 to - 0.12, p = 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses > 400 mg/day and study duration ˃ 12 weeks. CONCLUSION: Our review confirms that resveratrol supplementation reduces BW, BMI, WC, and body fat, particularly on doses > 400 mg/day and interventions lasting ˃12 weeks, with small effect sizes. Based on our findings, resveratrol supplementation could be considered as a complementary therapy in the management of obesity.

Key Findings

Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: - 0.18 kg, 95% CI - 0.32 to - 0.03, p = 0.02), BMI (ES: - 0.14 kg/m2, 95% CI - 0.2 to - 0.08, p < 0.001), WC (ES - 0.43 cm, 95% CI - 0.64 to - 0.22, p < 0.001), and body fat (ES: - 0.3 kg, 95% CI - 0.48 to - 0.12, p = 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses > 400 mg

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Resveratrol
  • Obesity
  • Body Mass Index
  • Waist Circumference
  • Dietary Supplements
  • Body Weight
  • Meta-Analysis as Topic
  • Adipose Tissue

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09