Ginger (Zingiber Officinale) Supplementation and Biomarkers of Cardiovascular Disease - A Systematic Review

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Ginger (Zingiber Officinale) Supplementation and Biomarkers of Cardiovascular Disease - A Systematic Review

Rjabi et al., 2026 | J Diet Suppl | Systematic Review

Citation

Rjabi Shrin, Dabirian Nasrin, ... Askarpour Moein. Ginger (Zingiber Officinale) Supplementation and Biomarkers of Cardiovascular Disease - A Systematic Review. J Diet Suppl. 2026;23(1):118-149. doi:10.1080/19390211.2025.2583512

Abstract

Ginger (Zingiber officinale) is one of the most widely used plant extracts and has been associated with improvements in biomarkers relevant to cardiovascular disease. Given the global burden of cardiovascular disease, this systematic review of randomized controlled trials aimed to evaluate the effects of ginger (Zingiber officinale) supplementation on biomarkers of cardiovascular disease. A systematic search of PubMed, Scopus, Web of Science Core Collection, and Google Scholar was performed up to January 2025 to identify eligible RCTs evaluating ginger supplementation. Outcomes included lipid profile, glycemic markers, blood pressure, inflammatory indicators, and liver enzymes. Data were pooled using weighted mean differences (WMDs). Subgroup and meta-regression analyses were conducted. Forty-one RCTs were included. Ginger supplementation was effective in improving FBS (WMD = -12.79 mg/dL; 95% CI = -18.57), insulin (WMD = -1.33 µIU/ml; 95% CI = -1.94, -0.71), HOMA-IR (WMD = -0.51; 95% CI = -0.68, -0.33), HbA1c (WMD = -0.68%; 95% CI = -1.00, -0.36), TG (WMD = -11.98 mg/dL; 95% CI = -23.27, -0.69), LDL (WMD = -4.55 mg/dL; 95% CI = -8.43, -0.68), HDL (WMD = 0.80 mg/dL; 95% CI = 0.01, 1.59), SBP (WMD = -2.72 mmHg; 95% CI = -5.25, -0.19), and ICAM-1 (WMD = -20.26 ng/ml; 95% CI = -40.49, -0.03). Ginger supplementation was not effective on the remaining outcomes. Ginger supplementation may improve several biomarkers of cardiovascular disease, with stronger effects in unhealthy individuals. Further studies are required to establish a clear cutoff for optimal dosage and intervention duration.

Key Findings

Further studies are required to establish a clear cutoff for optimal dosage and intervention duration.

Outcomes Measured

  • blood pressure
  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Zingiber officinale
  • Humans
  • Biomarkers
  • Dietary Supplements
  • Cardiovascular Diseases
  • Randomized Controlled Trials as Topic
  • Plant Extracts
  • Blood Glucose
  • Lipids
  • Insulin
  • Blood Pressure

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginger

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09