Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis

source extracted confidence: high 2026-04-09
#humans #fibromyalgia #vitamin-d #dietary-supplements #quality-of-life

Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis

Ilari et al., 2025 | Nutrients | Meta Analysis

Citation

Ilari Sara, Nucera Saverio, ... Muscoli Carolina. Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis. Nutrients. 2025-Oct-15;17(20). doi:10.3390/nu17203232

Abstract

Background: Fibromyalgia is a chronic condition characterized by widespread pain, fatigue, and localized tenderness. Its pathophysiology remains unclear, and treatment options are often limited and only partially effective. Recent studies suggest a potential link between vitamin D deficiency and symptom severity, as vitamin D may play a role in modulating pain and inflammation. Methods: This systematic review and meta-analysis assessed the efficacy of vitamin D supplementation in reducing pain and improving quality of life in fibromyalgia patients, focusing on studies up to 31 December 2024. Following PRISMA guidelines, a literature search in PubMed, Web of Science, and Scopus identified 2776 articles; 7 were included in the systematic review and 4 studies in each meta-analysis. Results: Results showed that vitamin D supplementation significantly reduced pain levels compared to the control group, with a statistically significant effect observed using the NRS or VAS (SMD = -0.85; 95% CI: -1.54 to -0.17; p = 0.0148), as well as the FIQ scale (SMD = -0.87; 95% CI: -1.56 to -0.20; p= 0.0115), resulting in an improvement in quality of life. Conclusions: These findings suggest that vitamin D may be a valuable adjunct in fibromyalgia management, particularly for pain. However, further high-quality trials are needed to confirm these effects and identify responsive patient subgroups.

Key Findings

Results showed that vitamin D supplementation significantly reduced pain levels compared to the control group, with a statistically significant effect observed using the NRS or VAS (SMD = -0.85; 95% CI: -1.54 to -0.17; p = 0.0148), as well as the FIQ scale (SMD = -0.87; 95% CI: -1.56 to -0.20; p= 0.0115), resulting in an improvement in quality of life. Conclusions: These findings suggest that vitamin D may be a valuable adjunct in fibromyalgia management, particularly for pain. However, further

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 4
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Fibromyalgia
  • Vitamin D
  • Dietary Supplements
  • Quality of Life
  • Vitamin D Deficiency
  • Female
  • Pain
  • Treatment Outcome
  • Pain Management
  • Middle Aged

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09