Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors

source extracted confidence: high 2026-04-09
#humans #breast-neoplasms #female #testosterone #vitamin-d

Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors

Minopoli et al., 2025 | Int J Mol Sci | Rct

Citation

Minopoli Anita, Di Gennaro Piergiacomo, ... Augustin Livia S A. Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors. Int J Mol Sci. 2025-Oct-15;26(20). doi:10.3390/ijms262010030

Abstract

Vitamin D plays a key role in immune modulation, cell proliferation, and hormone regulation. Dysregulated testosterone may contribute to breast cancer progression. We investigated whether long-term vitamin D supplementation affects serum testosterone levels in breast cancer survivors. Complete data at baseline, 12, and 24 months were derived from 253 women with early-stage breast cancer participating in the DEDiCa trial and randomized to receive either a high-dose vitamin D to maintain serum 25(OH)D at 60 ng/mL (group A) or a standard dose to maintain serum levels at 30 ng/mL (group B). Serum 25(OH)D levels significantly increased in both groups (p < 0.001). No significant changes in testosterone concentrations were observed between treatment groups over the 24 month treatment period (A: 0.125 to 0.140 ng/mL; B: 0.162 to 0.193 ng/mL; p = 0.682). Baseline serum testosterone levels emerged as the most significant predictor of testosterone trajectories, possibly modulated by hormone-suppressive therapy. These results are reassuring that vitamin D supplementation did not adversely affect testosterone levels in this population of breast cancer survivors and may partially concur with a healthy lifestyle to equilibrate testosterone levels.

Key Findings

These results are reassuring that vitamin D supplementation did not adversely affect testosterone levels in this population of breast cancer survivors and may partially concur with a healthy lifestyle to equilibrate testosterone levels.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Breast Neoplasms
  • Female
  • Testosterone
  • Vitamin D
  • Cancer Survivors
  • Middle Aged
  • Dietary Supplements
  • Aged
  • Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: vitamin-d-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09