Systematic review and pharmacological insights of ginsenoside Rf: Current status and future perspectives

source extracted confidence: high 2026-04-09
#ginsenosides #humans #panax #animals #neuroprotective-agents

Systematic review and pharmacological insights of ginsenoside Rf: Current status and future perspectives

Li et al., 2025 | Phytomedicine | Systematic Review

Citation

Li Ping, Zhao Li-Chun, ... Li Wei. Systematic review and pharmacological insights of ginsenoside Rf: Current status and future perspectives. Phytomedicine. 2025-Nov-25;148:157403. doi:10.1016/j.phymed.2025.157403

Abstract

BACKGROUND: Ginsenoside Rf (Rf), a protopanaxatriol-type saponin mainly found in Panax ginseng C.A. Meyer has drawn significant attention in recent years due to its diverse pharmacological activities. PURPOSE: This review aims to systematically consolidate current knowledge on Rf, focusing on its structural features, content quantification methods, and isolation and purification techniques, delving into its wide-ranging pharmacological actions. METHODS: Relevant keywords were used to search databases such as PubMed, Web of Science, ScienceDirect, and CNKI to collect and integrate Rf-related research data. RESULTS: Through summarizing the existing research progress, we found that Rf has pharmacological effects such as neuroprotection, cardiovascular regulation, analgesia, anti-inflammation, immunomodulation, antitumor activities, and metabolic regulation. This mini-review also delves into the pharmacokinetics of Rf and the potential for future studies, intending to offer a comprehensive insight into Rf and its possible application in medical and pharmacological domains.

Key Findings

Through summarizing the existing research progress, we found that Rf has pharmacological effects such as neuroprotection, cardiovascular regulation, analgesia, anti-inflammation, immunomodulation, antitumor activities, and metabolic regulation. This mini-review also delves into the pharmacokinetics of Rf and the potential for future studies, intending to offer a comprehensive insight into Rf and its possible application in medical and pharmacological domains.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition inflammation

MeSH Terms

  • Ginsenosides
  • Humans
  • Panax
  • Animals
  • Neuroprotective Agents
  • Anti-Inflammatory Agents

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09