The Association Between Green Tea Intake and Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials

source extracted confidence: high 2026-04-09
#humans #metabolic-syndrome #tea #randomized-controlled-trials-as-topic #blood-pressure

The Association Between Green Tea Intake and Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Ghoflchi et al., 2025 | Clin Ther | Meta Analysis

Citation

Ghoflchi Sahar, Mohammadi Hadiseh, ... Hosseini Hossein. The Association Between Green Tea Intake and Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Clin Ther. 2025-Dec;47(12):e1-e9. doi:10.1016/j.clinthera.2025.09.011

Abstract

INTRODUCTION: This review is the first to assess the effects of green tea on blood pressure, lipid profile, and glucose in people with metabolic syndrome, highlighting its potential anti-inflammatory and metabolic benefits. METHODS: We used Standardized Mean Differences (SMD) and Cohen's d for group comparisons, while heterogeneity and publication bias were assessed using the I² statistic, Cochrane Q test, Begg's funnel plot, and Egger's test. RESULTS: Our results showed that green tea consumption did not significantly affect FBS (SMD: -0.03; 95%; P = 0.95), HbA1C (SMD: 4.87; 95%; P = 0.63), systolic blood pressure (SMD: -0.42; 95%; P = 0.36), diastolic blood pressure (SMD: -0.24; 95%; P = 0.53), total cholesterol (SMD: -0.38; 95%; P = 0.19), TG (SMD: -0.17; 95%; P = 0.34), HDL-C (SMD: -0.07; 95%; P = 0.75), or LDL-C (SMD: -0.45; 95%; P = 0.25). Subgroup analyses showed that short-term green tea intake (<8 weeks) significantly reduced FBS (SMD: -1.62), total cholesterol (SMD: -1.09), TG (SMD: -0.74), and LDL-C (SMD: -0.83). Doses below 3000 mg/day were also linked to lower total cholesterol (SMD: -0.69) and LDL-C (SMD: -0.83). Among women, green tea improved total cholesterol (SMD: -0.79), HDL-C (SMD: 0.50), LDL-C (SMD: -1.25), and systolic blood pressure (SMD: -1.74), despite overall high heterogeneity and publication bias. CONCLUSION: Although our results found no significant difference in the measurement factor in patients with MetS. subgroup analyses suggested potential benefits in women, those consuming lower doses (<3000 mg/day), and those with shorter intervention durations (<8 weeks).

Key Findings

Our results showed that green tea consumption did not significantly affect FBS (SMD: -0.03; 95%; P = 0.95), HbA1C (SMD: 4.87; 95%; P = 0.63), systolic blood pressure (SMD: -0.42; 95%; P = 0.36), diastolic blood pressure (SMD: -0.24; 95%; P = 0.53), total cholesterol (SMD: -0.38; 95%; P = 0.19), TG (SMD: -0.17; 95%; P = 0.34), HDL-C (SMD: -0.07; 95%; P = 0.75), or LDL-C (SMD: -0.45; 95%; P = 0.25). Subgroup analyses showed that short-term green tea intake (<8 weeks) significantly reduced FBS (SMD

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure
  • inflammatory markers

Population

Field Value
Population mets
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Humans
  • Metabolic Syndrome
  • Tea
  • Randomized Controlled Trials as Topic
  • Blood Pressure
  • Blood Glucose
  • Lipids
  • Female
  • Male

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: green-tea-metabolic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09