Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions
Leiva-Castro et al., 2025 | Inflammopharmacology | Systematic Review
Citation
Leiva-Castro Camila, Múnera-Rodríguez Ana M, ... López-Enríquez Soledad. Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions. Inflammopharmacology. 2025-Nov;33(11):6357-6375. doi:10.1007/s10787-025-01976-8
Abstract
Rheumatoid arthritis is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. The gut microbiome has emerged as a key factor in the regulation of the immune system, and its dysbiosis has been implicated in the pathogenesis of rheumatoid arthritis. Nutraceuticals, including probiotics, omega-3 fatty acids, coenzyme Q10, vitamin D, and polyphenols, have shown potential in modulating the gut microbiota and inflammatory pathways. This review explores the interplay between nutraceuticals, gut microbiota, and immune function in rheumatoid arthritis, with attention to pharmacokinetics and safety. We discuss recent clinical evidence, elucidate molecular mechanisms of action, and highlight future research directions for integrating nutraceuticals into therapeutic strategies for rheumatoid arthritis.
Key Findings
We discuss recent clinical evidence, elucidate molecular mechanisms of action, and highlight future research directions for integrating nutraceuticals into therapeutic strategies for rheumatoid arthritis.
Outcomes Measured
- inflammatory markers
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | inflammation |
MeSH Terms
- Humans
- Arthritis, Rheumatoid
- Dietary Supplements
- Oxidative Stress
- Gastrointestinal Microbiome
- Inflammation
- Animals
- Fatty Acids, Omega-3
- Probiotics
- Ubiquinone
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: coq10
Provenance
- PMID: 41026372
- DOI: 10.1007/s10787-025-01976-8
- PMCID: PMC12618442
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09