Melatonin for blood pressure control in adults

source extracted confidence: high 2026-04-09
#adult #humans #antihypertensive-agents #blood-pressure #delayed-action-preparations

Melatonin for blood pressure control in adults

Zia et al., 2025 | Cochrane Database Syst Rev | Other

Citation

Zia Ul Haq Muhammad, Mansoor Javeria, ... Harzand Arash. Melatonin for blood pressure control in adults. Cochrane Database Syst Rev. 2025-Sep-16;9(9):CD016159. doi:10.1002/14651858.CD016159

Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Critical objective To assess the effects of oral melatonin supplementation (immediate‑release (IR) and controlled‑/sustained‑release CR/SR; any dose; ≥ 1 week) versus placebo or no treatment on change in systolic and diastolic blood pressure (SBP, DBP) in adults. Important objectives To examine dose‑response relationships between melatonin dose and changes in SBP and DBP. To assess effects by key participant and intervention characteristics (prespecified subgroups): baseline blood pressure status; concomitant antihypertensive medication use; presence of diagnosed sleep disorder/insomnia; melatonin formulation (IR versus CR/SR); blood pressure measurement method (office versus ambulatory versus home; daytime versus nocturnal); age (< 65 versus ≥ 65 years); sex. To evaluate adverse events (serious and non‑serious) and select patient‑important outcomes (quality of life, sleep quality). To describe any reported longer‑term cardiovascular outcomes (e.g. incident cardiovascular disease events, mortality) when sufficient data are available. These analyses are exploratory given anticipated sparse data.

Key Findings

These analyses are exploratory given anticipated sparse data.

Outcomes Measured

  • sleep quality
  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition insomnia

MeSH Terms

  • Adult
  • Humans
  • Antihypertensive Agents
  • Blood Pressure
  • Delayed-Action Preparations
  • Hypertension
  • Melatonin
  • Randomized Controlled Trials as Topic
  • Review Literature as Topic

Evidence Classification

  • Level: Other
  • Publication Types: Journal Article
  • Vertical: melatonin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09