Dietary Vitamin K Intake and Fracture Risk: A Systematic Review and Dose-Response Meta-Analysis on the Interplay with Vitamin D

source extracted confidence: high 2026-04-09

Dietary Vitamin K Intake and Fracture Risk: A Systematic Review and Dose-Response Meta-Analysis on the Interplay with Vitamin D

Haghighat et al., 2025 | Curr Rheumatol Rev | Meta Analysis

Citation

Haghighat Mohammad Mehdi Lari, Haghpanah Babak, Milajerdi Alireza. Dietary Vitamin K Intake and Fracture Risk: A Systematic Review and Dose-Response Meta-Analysis on the Interplay with Vitamin D. Curr Rheumatol Rev. 2025-Sep-09. doi:10.2174/0115733971393704250828112958

Abstract

BACKGROUND: Fractures are a significant global health issue, particularly among older adults, and are associated with substantial morbidity and mortality. While several risk factors are well-established, the role of dietary vitamin K in fracture prevention remains unclear, with existing epidemiological studies yielding inconsistent results. OBJECTIVE: This meta-analysis aimed to comprehensively evaluate the association between dietary vitamin K intake and the risk of fractures, including a dose-response analysis to explore potential non-linear relationships. METHODS: A comprehensive search was conducted in the PubMed and EMBASE databases, covering the period from January 1966 to July 2025. The certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework. RESULTS: A total of six studies encompassing 93,776 participants and 1394 instances of fractures were analyzed. We found a trend towards a decreased risk of overall fractures with increased vitamin K consumption, with a risk ratio of 0.83 (95% CI, 0.68-1.01). Similarly, vitamin K intake showed a trend toward a reduced risk of hip fractures (risk ratio: 0.76, 95% CI: 0.56-1.02; I2 = 43.91%). Furthermore, the risk of overall fractures decreased with dietary vitamin K consumption up to 120 μg/day. CONCLUSIONS: Our meta-analysis suggests that dietary vitamin K intake may have a protective effect against fractures. We observed a U-shaped association between fracture risk and vitamin K intake at recommended dietary allowance (RDA) levels. Further studies in diverse populations, examining different forms of vitamin K and their relation to fracture risk at various skeletal sites, are warranted. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 1016592.

Key Findings

A total of six studies encompassing 93,776 participants and 1394 instances of fractures were analyzed. We found a trend towards a decreased risk of overall fractures with increased vitamin K consumption, with a risk ratio of 0.83 (95% CI, 0.68-1.01). Similarly, vitamin K intake showed a trend toward a reduced risk of hip fractures (risk ratio: 0.76, 95% CI: 0.56-1.02; I2 = 43.91%). Furthermore, the risk of overall fractures decreased with dietary vitamin K consumption up to 120 μg/day.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population older adults
Sample Size 93776
Age Range See abstract
Condition See abstract

MeSH Terms

  • No MeSH terms indexed

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: vitamin-k

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09