Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#curcumin #colorectal-neoplasms #animals #antineoplastic-agents-phytogenic #humans

Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and meta-analysis

Jia et al., 2026 | J Ethnopharmacol | Meta Analysis

Citation

Jia Yongheng, Liu Xianjun, ... Xu Zhonghang. Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and meta-analysis. J Ethnopharmacol. 2026-Jan-10;354:120511. doi:10.1016/j.jep.2025.120511

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine (TCM), Curcuma longa L. has been used since ancient times to treat chest and abdominal distending pain caused by cold coagulation, qi stagnation, and blood stasis, as well as cold-bi syndrome shoulder-arm pain. Colorectal cancer (CRC) falls under the categories of "Jiju" (Mass Accumulation) in TCM. The core pathogenesis involves spleen deficiency, dampness-toxin accumulation, and blood stasis, which are closely related to qi circulation stagnation, blood stasis, and phlegm coagulation. Curcuma longa L. is pungent and warm in nature, with the effects of "breaking blood to eliminate masses and promoting qi to resolve stagnation". Curcumin, a polyphenolic compound, is the main pharmacological component extracted from the rhizomes of Curcuma longa L. Modern pharmacological studies have found that curcumin exhibits multiple pharmacological activities, including anti-inflammatory, anti-tumor, anti-angiogenic, anti-metastatic, and anti-multidrug resistance effects. AIM OF THE STUDY: This study aimed to evaluate the efficacy of curcumin in animal models of colorectal cancer and explore its mechanism of action. MATERIALS AND METHODS: Databases including Embase, Web of Science, PubMed, China National Knowledge Infrastructure, and Wanfang Database were searched from their inception to March 2025. The primary outcomes were reduction in tumor volume and weight, with subgroup analyses additionally conducted. RESULTS: The analysis included 22 studies involving 536 animals. The results of the studies showed that Curcumin administration resulted in a significant reduction in tumor volume and a decrease in tumor weight relative to controls. In addition, the combination of Curcumin and chemotherapeutic agents had a synergistic effect, significantly reduced the volume and weight of CRC tumors relative to chemotherapeutic agents alone. Subgroup analyses showed that the efficacy of the oral route of Curcumin administration was superior to that of other routes of administration. Dose-response analysis suggested that the optimal dose range of Curcumin was 25-50 mg/kg/day and the duration of intervention was 14-21 days. CONCLUSION: Curcumin can significantly inhibit the growth of CRC, attributed to its various anticancer properties such as modulation of intestinal microbes, alleviation of intestinal inflammation, inhibition of tumor cell proliferation, promotion of apoptosis, inhibition of metastasis, and sensitization to chemotherapy. However, clinical trials are still needed to evaluate the efficacy of Curcumin in humans.

Key Findings

The analysis included 22 studies involving 536 animals. The results of the studies showed that Curcumin administration resulted in a significant reduction in tumor volume and a decrease in tumor weight relative to controls. In addition, the combination of Curcumin and chemotherapeutic agents had a synergistic effect, significantly reduced the volume and weight of CRC tumors relative to chemotherapeutic agents alone. Subgroup analyses showed that the efficacy of the oral route of Curcumin adminis

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 22
Age Range See abstract
Condition deficiency

MeSH Terms

  • Curcumin
  • Colorectal Neoplasms
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Humans
  • Disease Models, Animal
  • Curcuma
  • Medicine, Chinese Traditional

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: curcumin-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09