Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis

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#humans #hashimoto-disease #selenium #dietary-supplements #thyrotropin

Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis

Zhang et al., 2025 | Medicine (Baltimore) | Meta Analysis

Citation

Zhang Heng, Yang Yunkai, ... Liu Zhelong. Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2025-Aug-29;104(35):e44043. doi:10.1097/MD.0000000000044043

Abstract

BACKGROUND: To assess the clinical benefits of Selenium (Se) supplementation in patients with Hashimoto thyroiditis (HT). METHODS: Eight databases were searched for randomized controlled trials. The outcomes of interest were thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4). The study protocol is registered on INPLASY, DOI number is 10.37766/inplasy2022.10.0085. RESULTS: Twenty-one studies with a total of 1610 subjects were included. Serum TPOAb was significantly reduced after Se supplementation after 3 months (standardized mean difference [SMD] = -0.46, 95% confidence interval [CI]: -0.74 to -0.18, P = .001) and 6 months (SMD = -0.80, 95%CI: -1.38 to -0.21, P = .008). The serum TgAb levels decreased at 3 months (SMD = -0.46, 95%CI: -0.79 to -0.12, P = .007) but not at 6 months. Significant effects on declining the TSH titers were found after 6 months (SMD = -0.18, 95%CI = -0.35 to -0.01; P = .03). CONCLUSION: Se supplementation help reduce TPOAb and TSH levels in HT patients, leading to improvements in well-being or mood. Selenomethionine is more effective than NaSe and Se-yeast in the teatment of Hashimoto thyroid.

Key Findings

Twenty-one studies with a total of 1610 subjects were included. Serum TPOAb was significantly reduced after Se supplementation after 3 months (standardized mean difference [SMD] = -0.46, 95% confidence interval [CI]: -0.74 to -0.18, P = .001) and 6 months (SMD = -0.80, 95%CI: -1.38 to -0.21, P = .008). The serum TgAb levels decreased at 3 months (SMD = -0.46, 95%CI: -0.79 to -0.12, P = .007) but not at 6 months. Significant effects on declining the TSH titers were found after 6 months (SMD = -0.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population hashimoto thyroiditis
Sample Size 1610
Age Range See abstract
Condition mood

MeSH Terms

  • Humans
  • Hashimoto Disease
  • Selenium
  • Dietary Supplements
  • Thyrotropin
  • Randomized Controlled Trials as Topic
  • Thyroxine
  • Autoantibodies
  • Treatment Outcome
  • Triiodothyronine
  • Iodide Peroxidase

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: selenium-thyroid

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09