A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders

source extracted confidence: high 2026-04-09
#humans #nf-e2-related-factor-2 #neurodegenerative-diseases #biological-products #kelch-like-ech-associated-protein-1

A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders

Gote et al., 2025 | Inflammopharmacology | Systematic Review

Citation

Gote Sharmila, Dubey Sonal, ... Thapa Shankar. A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders. Inflammopharmacology. 2025-Sep;33(9):5097-5111. doi:10.1007/s10787-025-01917-5

Abstract

Neurodegenerative disease represents a significant public health concern, with conditions, such as Alzheimer's disease and Parkinson's disease, being among the most prevalent. The primary risk factor for these neurodegenerative diseases is the process of aging. Key factors, such as oxidative stress and mitochondrial dysfunction, play a crucial role in initiating neurodegeneration. The progressive deterioration and neuronal loss in both the central and peripheral nervous systems are hallmark features of neurodegenerative diseases. Plant-derived natural products and their bioactive components, such as curcumin, resveratrol, genistein, marine algae, quercetin, apigenin, and luteolin, have shown promise as therapeutic agents for treating neurodegenerative diseases. There are various medications approved for the management of neurodegenerative diseases; their usage is primarily limited to providing symptomatic relief. The utilization of natural products holds significant promise for the prevention and treatment of neurodegenerative diseases (ND). The review provides evidence that natural products and their bioactive compounds could be beneficial in the treatment of neurodegenerative disorders. This article delineates the Keap1-Nrf2-ARE pathway's role in ND progression, shedding light on the therapeutic efficacy of natural products and their bioactive constituents that have demonstrated neuroprotective properties.

Key Findings

This article delineates the Keap1-Nrf2-ARE pathway's role in ND progression, shedding light on the therapeutic efficacy of natural products and their bioactive constituents that have demonstrated neuroprotective properties.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Humans
  • NF-E2-Related Factor 2
  • Neurodegenerative Diseases
  • Biological Products
  • Kelch-Like ECH-Associated Protein 1
  • Animals
  • Signal Transduction
  • Oxidative Stress
  • Neuroprotective Agents
  • Antioxidant Response Elements

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09