Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09

Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis

Wu et al., 2025 | Front Pharmacol | Systematic Review

Citation

Wu Weidong, Meng Tianwei, ... Zhou Yanyan. Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis. Front Pharmacol. 2025;16:1588284. doi:10.3389/fphar.2025.1588284

Abstract

OBJECTIVES: This meta-analysis aims to systematically evaluate the impact of resveratrol on postmenopausal women. METHODS: We searched seven electronic databases and conducted meta-analyses using Stata 12.0. RESULTS: Ten randomized controlled trials (RCTs) with 928 participants were identified. Resveratrol significantly reduced pain scores (WMD: -2.841, 95% CI: -5.631 to -0.050, p = 0.046), pain VAS scores (WMD: -7.585, 95% CI: -12.912 to -2.257, p = 0.005), PPI scores (WMD: -8.563, 95% CI: -12.866 to -4.261, p < 0.001), and CTX levels (WMD: -0.137, 95% CI: -0.204 to -0.070, p < 0.001). However, no significant effects were observed on cognition and memory (e.g., PVT, ORR, PSM, RAVLT, LSWM, FSS, DCCS, FICA, TMT), mood (depression, overall mood), metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C), blood pressure, sleep disturbance, menopausal symptoms, SF-36 quality of life, or bone markers ALP and OC. CONCLUSION: Resveratrol may improve pain and bone metabolism (CTX) in postmenopausal women but did not affect other examined outcomes. Future large-scale trials are needed to confirm these findings and determine optimal dosing and treatment strategies. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier CRD42024566807.

Key Findings

Ten randomized controlled trials (RCTs) with 928 participants were identified. Resveratrol significantly reduced pain scores (WMD: -2.841, 95% CI: -5.631 to -0.050, p = 0.046), pain VAS scores (WMD: -7.585, 95% CI: -12.912 to -2.257, p = 0.005), PPI scores (WMD: -8.563, 95% CI: -12.866 to -4.261, p < 0.001), and CTX levels (WMD: -0.137, 95% CI: -0.204 to -0.070, p < 0.001). However, no significant effects were observed on cognition and memory (e.g., PVT, ORR, PSM, RAVLT, LSWM, FSS, DCCS, FICA, T

Outcomes Measured

  • depression
  • blood pressure

Population

Field Value
Population postmenopausal women
Sample Size 928
Age Range See abstract
Condition sleep

MeSH Terms

  • No MeSH terms indexed

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09