Myonectin and metabolic health: a systematic review

source extracted confidence: high 2026-04-09
#humans #animals #metabolic-diseases #lipid-metabolism #signal-transduction

Myonectin and metabolic health: a systematic review

Petro et al., 2025 | Front Endocrinol (Lausanne) | Systematic Review

Citation

Petro Jorge L, Gallo-Villegas Jaime, Calderón Juan C. Myonectin and metabolic health: a systematic review. Front Endocrinol (Lausanne). 2025;16:1557142. doi:10.3389/fendo.2025.1557142

Abstract

Myonectin is a myokine with a potential role in metabolic health. This is a bibliometric and bioinformatics-complemented systematic review aimed to comprehensively analyze the structure, regulation and effects of myonectin on metabolic outcomes relevant to the pathophysiology of chronic metabolic diseases. Fifty-three studies involving cellular, animal, and human models were included. Findings indicate that myonectin is induced by aerobic exercise, nutrients, epinephrin, hypoxia and curcumin but is downregulated by obesity and muscle dysfunction. Evidence suggests that myonectin regulates lipid uptake and distribution across tissues, reduces inflammation and apoptosis and modulates mitochondrial function likely through the activation of AKT and AMP-activated protein kinase (AMPK)-mediated signaling pathways. While most results arising from human studies of good quality are in agreement with animal and cellular data, controversy remains and we discuss challenges and perspectives in the field. In conclusion, myonectin has a diverse role in regulating metabolic health, but a key contribution pertains to lipid regulation, which likely leads to a healthy expansion and distribution of adipose tissue.

Key Findings

In conclusion, myonectin has a diverse role in regulating metabolic health, but a key contribution pertains to lipid regulation, which likely leads to a healthy expansion and distribution of adipose tissue.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition inflammation

MeSH Terms

  • Humans
  • Animals
  • Metabolic Diseases
  • Lipid Metabolism
  • Signal Transduction

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09