A systematic review to compare adrenalectomy and mineralocorticoid receptor antagonists in patients with unilateral primary aldosteronism

source extracted confidence: high 2026-04-09
#humans #hyperaldosteronism #adrenalectomy #mineralocorticoid-receptor-antagonists

A systematic review to compare adrenalectomy and mineralocorticoid receptor antagonists in patients with unilateral primary aldosteronism

Yoshida et al., 2025 | Hypertens Res | Systematic Review

Citation

Yoshida Yuichi, Kinouchi Kenichiro, ... Mukoyama Masashi. A systematic review to compare adrenalectomy and mineralocorticoid receptor antagonists in patients with unilateral primary aldosteronism. Hypertens Res. 2025-Sep;48(9):2368-2375. doi:10.1038/s41440-025-02273-1

Abstract

To date, no systematic review has examined whether adrenalectomy (ADX) or mineralocorticoid receptor antagonist (MRA) treatment is more effective in patients with unilateral primary aldosteronism (uPA). Comparing clinical and biochemical data before and after treatment, we performed a systematic review to determine whether either ADX or MRA treatment is superior to the other in patients with uPA. Article search was performed using the PubMed, Cochrane Library, and ICHUSHI electronic databases. A comparative analysis was performed when at least 3 articles were available in each outcome. The collected data were used to calculate the effect measures represented as mean difference (MD) or odds ratio (OR). Our search strategy identified 526 abstracts, of which 7 research papers were finally included in the analysis. ADX for uPA patients significantly reduced the incidence of cerebro-cardiovascular disease (OR 0.63 [95% confidence interval 0.46, 0.85]), lowered the systolic BP (-8.78 mmHg [-11.61, -5.95]), and increased the serum potassium levels (0.43 mmol/L [0.35, 0.51]) compared to MRAs. In conclusion, ADX is more effective than MRA treatment in patients with uPA, but with higher risk of increased serum potassium levels. Graphical abstract: ADX adrenalectomy, MRAs mineralocorticoid receptor antagonists, PA primary aldosteronism, SBP systolic blood pressure.

Key Findings

Graphical abstract: ADX adrenalectomy, MRAs mineralocorticoid receptor antagonists, PA primary aldosteronism, SBP systolic blood pressure.

Outcomes Measured

  • blood pressure
  • systolic blood pressure

Population

Field Value
Population unilateral primary aldosteronism
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Humans
  • Hyperaldosteronism
  • Adrenalectomy
  • Mineralocorticoid Receptor Antagonists

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article, Comparative Study
  • Vertical: potassium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09