Efficacy of probiotics in dermatitis herpetiformis management: an umbrella review

source extracted confidence: high 2026-04-09

Efficacy of probiotics in dermatitis herpetiformis management: an umbrella review

Alghuyaythat et al., 2025 | Front Physiol | Systematic Review

Citation

Alghuyaythat Waleed Khalid Z, Alfaifi Fawziah Salman, ... Alluli Maryam Mohammed. Efficacy of probiotics in dermatitis herpetiformis management: an umbrella review. Front Physiol. 2025;16:1556998. doi:10.3389/fphys.2025.1556998

Abstract

BACKGROUND: The available evidence on probiotics in Dermatitis Herpetiformis (DH) remains severely limited. Given the shared pathophysiology of DH and Coeliac disease (CD), we aimed to provide the hypothesis to synthesize the narrative reviews carried out so far on the use of probiotics in the treatment of DH, its impact on gut microbiota dysbiosis, and the gut-skin axis. METHODS: Relevant narrative reviews were searched for in electronic databases such as PubMed, Scopus, Cochrane Library, Embase, and Google Scholar. RESULTS: All 7 included reviews commented on gut microbiota dysbiosis as a common feature in patients with CD and DH. Immune modulation, attenuation of intestinal permeability, and anti-inflammatory effects were some of the postulated effects of probiotics. Probiotics could modulate the gut-skin axis and may prove therapeutic for DH; however, most of the evidence was indirect, drawn from models of CD or theoretically derived. CONCLUSION: While probiotics showed promise for managing gut dysbiosis and immune regulation in DH, the existing evidence remains speculative. Our results suggest that probiotics could be a useful adjunct to gluten-free dieting in DH treatment, but future studies are needed to support this finding.

Key Findings

All 7 included reviews commented on gut microbiota dysbiosis as a common feature in patients with CD and DH. Immune modulation, attenuation of intestinal permeability, and anti-inflammatory effects were some of the postulated effects of probiotics. Probiotics could modulate the gut-skin axis and may prove therapeutic for DH; however, most of the evidence was indirect, drawn from models of CD or theoretically derived.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population cd and dh
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • No MeSH terms indexed

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: probiotics-skin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09