Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing deep caries in vital permanent teeth: A systematic review and meta-analysis

Herbst et al., 2025 | Int Endod J | Meta Analysis

Citation

Herbst Sascha R, Pitchika Vinay, ... Schwendicke Falk. Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing deep caries in vital permanent teeth: A systematic review and meta-analysis. Int Endod J. 2025-Aug;58(8):1110-1125. doi:10.1111/iej.14256

Abstract

BACKGROUND: Direct pulp capping (DPC) is the least minimal approach for maintaining pulp vitality after pulp exposure. Besides calcium hydroxide (CaOH), hydraulic calcium silicate cements (HCSC) have increasingly been used for DPC. OBJECTIVES: During the S3 level guideline development for material choice in DPC, we conducted a systematic review and meta-analysis of existing literature comparing CaOH and HCSC for DPC on permanent teeth. We aimed (1) to assess clinical and radiographic outcomes and (2) patient-reported outcomes of DPC. METHOD: Three databases from 1 January 1990 to 19 February 2025 (MEDLINE via PubMed, EMBASE and Cochrane Database of Systematic Reviews). Prospective comparative clinical studies comparing CaOH to HCSC for DPC in permanent teeth with healthy or reversibly inflamed pulps were included. Studies on primary teeth or teeth indicative of irreversible pulpitis, teeth with unclear diagnoses or pulp exposure of non-cariogenic origin were excluded. The risk of bias and certainty of evidence were evaluated using the GRADE approach. Using the effect sizes and standard errors for every study, pairwise meta-analysis was performed comparing CaOH and different subgroups of HCSC. Success was defined as the absence of any clinical symptoms (e.g. pain, swelling) and any radiographical signs of an apical lesion. Patient-reported outcomes were additionally sought after. RESULTS: Five randomized-controlled trials including 552 teeth with an overall moderate certainty of evidence were included. HCSC showed a significantly higher probability of success compared to CaOH (Odds Ratio (OR): 2.68, 95% confidence interval [1.7, 4.22], I2 = 0%). The differences between various HCSC materials were minimal. Meta-regression indicated that neither follow-up nor risk of bias significantly influenced treatment outcomes, and the funnel plot did not reveal evidence of publication bias. CONCLUSION: HCSC showed significantly higher probability for clinical and radiographic success than CaOH. This finding comes with moderate certainty. The impact of material choice on postoperative pain remains unclear. Future clinical studies should include patient-reported outcomes.

Key Findings

Five randomized-controlled trials including 552 teeth with an overall moderate certainty of evidence were included. HCSC showed a significantly higher probability of success compared to CaOH (Odds Ratio (OR): 2.68, 95% confidence interval [1.7, 4.22], I2 = 0%). The differences between various HCSC materials were minimal. Meta-regression indicated that neither follow-up nor risk of bias significantly influenced treatment outcomes, and the funnel plot did not reveal evidence of publication bias.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Humans
Calcium Hydroxide
Dental Pulp Capping
Calcium Compounds
Silicates
Dental Caries
Dentition, Permanent
Pulp Capping and Pulpectomy Agents
Dental Cements
Silicate Cement

Evidence Classification

Level: Meta Analysis
Publication Types: Journal Article, Systematic Review, Meta-Analysis, Comparative Study
Vertical: calcium

Provenance

PMID: 40394883
DOI: 10.1111/iej.14256
PMCID: PMC12254524
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09