Percutaneous Ablation of Parathyroid Adenomas: A Systematic Review and Meta-Analysis

source extracted confidence: high 2026-04-09
#humans #parathyroid-neoplasms #adenoma #ablation-techniques #treatment-outcome

Percutaneous Ablation of Parathyroid Adenomas: A Systematic Review and Meta-Analysis

Bilgin et al., 2025 | J Clin Endocrinol Metab | Meta Analysis

Citation

Bilgin Cem, Hibbert Rebecca, ... Parvinian Ahmad. Percutaneous Ablation of Parathyroid Adenomas: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2025-Aug-07;110(9):e3150-e3162. doi:10.1210/clinem/dgaf270

Abstract

BACKGROUND: Percutaneous ablation of parathyroid adenomas provides a minimally invasive treatment option for primary hyperparathyroidism. However, the overall performance of this technique remains underexplored. This meta-analysis evaluates the effectiveness and safety of various ablation techniques for parathyroid adenomas. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, multiple databases, including Ovid MEDLINE and Cochrane, were systematically searched. Studies that provided separate data for radiofrequency (RF), microwave ablation (MWA), and ethanol ablation technique were included. Outcomes of interest were changes in serum calcium, PTH, and phosphorus levels, along with normocalcemia rates at 6 to 12 months after ablation. Safety outcomes included transient hoarseness, permanent hoarseness, severe hemorrhage, major complications, and severe hypocalcemia. Data were pooled using a random-effects model, with pooled prevalence and 95% CIs calculated. Also, the publication bias was assessed with Egger's test for each outcome measure. RESULTS: Twenty studies (815 patients) were included. The posttreatment normocalcemia rate at 6 to 12 months was 85.6% (95% CI, 80.48-90.72). Serum PTH and calcium levels significantly decreased, with mean differences of 101.49 pg/mL (95% CI, 73.50-129.48) and 0.39 mmol/L (95% CI, 0.34-.45), respectively. Permanent hoarseness and major complications were rare, with incidences of 0.28% (95% CI, 0.00-1.05) and 0.31% (95% CI, 0.00-1.09). The safety and efficacy outcomes of RF, MWA, and ethanol ablation were comparable. CONCLUSION: Our findings indicate that percutaneous ablation of parathyroid adenomas is safe and effective within the first year of the treatment. Additionally, they suggest that RF, MWA, and ethanol ablation techniques can each be employed depending on patients' needs without particular limitations.

Key Findings

Twenty studies (815 patients) were included. The posttreatment normocalcemia rate at 6 to 12 months was 85.6% (95% CI, 80.48-90.72). Serum PTH and calcium levels significantly decreased, with mean differences of 101.49 pg/mL (95% CI, 73.50-129.48) and 0.39 mmol/L (95% CI, 0.34-.45), respectively. Permanent hoarseness and major complications were rare, with incidences of 0.28% (95% CI, 0.00-1.05) and 0.31% (95% CI, 0.00-1.09). The safety and efficacy outcomes of RF, MWA, and ethanol ablation were

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 815
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Parathyroid Neoplasms
  • Adenoma
  • Ablation Techniques
  • Treatment Outcome
  • Radiofrequency Ablation
  • Hyperparathyroidism, Primary
  • Catheter Ablation
  • Ethanol

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: calcium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09