The effect of vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials

source extracted confidence: high 2026-04-09
#humans #lipoproteins-ldl #vitamin-e #dietary-supplements #oxidation-reduction

The effect of vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials

Amini et al., 2025 | Eur J Pharmacol | Meta Analysis

Citation

Amini Sepide, Navab Fatemeh, ... Sahebkar Amirhossein. The effect of vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials. Eur J Pharmacol. 2025-Jun-15;997:177491. doi:10.1016/j.ejphar.2025.177491

Abstract

Oxidation of low-density lipoprotein (LDL) accelerates atherosclerosis. Vitamin E is a powerful fat-soluble antioxidant; some studies have shown its beneficial effects in reducing oxidized LDL levels. Due to the inconsistent reports, we performed a systematic review and meta-analysis to evaluate the impact of vitamin E supplementation on oxidation of LDL levels. PubMed, Scopus, Web of Science, and Google Scholar were systematically searched to find clinical trials published in English. A total of 21 records with 29 intervention arms were included in this review. In the meta-analysis of 6 studies that reported changes in oxidized LDL levels, a significant decrease in LDL oxidation was observed (95% CI: -1.44 [-2.5, -0.38]; I2 = 95.8%, P < 0.001; Tau-squared: 1.6171). Moreover, a meta-analysis of 7 studies that reported lag time as a measure of LDL oxidation showed that vitamin E supplementation significantly increased the lag time of LDL oxidation (95% CI: 20.45 [12.46, 28.43]; I2 = 95.9%, P < 0.001; Tau-squared: 103.3545). Two studies used the thiobarbituric acid-reactive substances (TBARS) assay to evaluate the susceptibility to LDL oxidation. One of them showed a significant decrease in LDL susceptibility to oxidation after supplementation with tocopherol, while the other one did not show a significant effect. Vitamin E significantly reduced the susceptibility of LDL to oxidation and increased the lag time of LDL oxidation.

Key Findings

Vitamin E significantly reduced the susceptibility of LDL to oxidation and increased the lag time of LDL oxidation.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 6
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Lipoproteins, LDL
  • Vitamin E
  • Dietary Supplements
  • Oxidation-Reduction
  • Clinical Trials as Topic
  • Antioxidants

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09