Micronutrient deficiencies in patients with celiac disease: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #celiac-disease #micronutrients #zinc #folic-acid

Micronutrient deficiencies in patients with celiac disease: A systematic review and meta-analysis

Lamjadli et al., 2025 | Int J Immunopathol Pharmacol | Meta Analysis

Citation

Lamjadli Saad, Oujamaa Ider, ... Admou Brahim. Micronutrient deficiencies in patients with celiac disease: A systematic review and meta-analysis. Int J Immunopathol Pharmacol. 2025;39:3946320241313426. doi:10.1177/03946320241313426

Abstract

This study aimed to characterize micronutrient deficiencies, including iron, ferritin, folic acid, vitamin D, zinc (Zn), vitamin B12, and copper, in patients with celiac disease, and evaluated the effects of these deficiencies on selected hematological parameters, including hemoglobin and mean corpuscular volume (MCV). Celiac disease (CeD), an immune-mediated disorder affecting the small bowel, is associated with genetic factors and micronutrient deficiencies. This meta-analysis was performed in accordance with the PRISMA guidelines. Literature searches of multiple databases retrieved 4140 studies, of which 45 were selected. Risk of Bias was performed in accordance with the STROBE checklist. Meta-analysis revealed a significant difference in hemoglobin levels between patients with CeD and controls (standardized mean difference (SMD) -0.59 (95% confidence interval (CI) -0.8459 to -0.3382); P = 0.0003). Iron levels were lower in patients with CeD (SMD ≈ -0.4 (95% CI -0.7385 to -0.0407); P = 0.0334), as were ferritin (SMD -0.6358 (95% CI -0.8962 to -0.3755); P = 0.0002), folic acid (SMD -0.5446 (95% CI -0.9749 to -0.1142); P = 0.0187), and vitamin D (SMD -0.4011 (95% CI -0.8020 to -0.0001); P = 0.0499) levels, while Zn levels were significantly reduced (SMD -1.1398 (95% CI -2.0712 to -0.2084); P = 0.0242). No significant differences were found in MCV, or copper or vitamin B12 levels between patients with CeD and controls. This study highlighted significantly higher micronutrient deficiencies in patients diagnosed with CeD than in controls, underscoring the importance of systematic nutritional assessment and multidisciplinary management to address micronutrient deficiencies and minimize negative health impact(s).

Key Findings

This study highlighted significantly higher micronutrient deficiencies in patients diagnosed with CeD than in controls, underscoring the importance of systematic nutritional assessment and multidisciplinary management to address micronutrient deficiencies and minimize negative health impact(s).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population celiac disease
Sample Size 4140
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Celiac Disease
  • Micronutrients
  • Zinc
  • Folic Acid
  • Iron
  • Ferritins
  • Hemoglobins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Systematic Review, Meta-Analysis, Journal Article
  • Vertical: vitamin-b12

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09