Effects of resveratrol on the lipid profile of post-menopause women: Systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#aged #female #humans #middle-aged #age-factors

Effects of resveratrol on the lipid profile of post-menopause women: Systematic review and meta-analysis

Rodrigues et al., 2025 | Nutr Metab Cardiovasc Dis | Meta Analysis

Citation

Rodrigues Uggioni Maria Laura, Ronsani Leticia, ... Colonetti Tamy. Effects of resveratrol on the lipid profile of post-menopause women: Systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2025-Apr;35(4):103827. doi:10.1016/j.numecd.2024.103827

Abstract

AIMS: Postmenopausal women experience an increase in cardiovascular, sexual, and emotional changes that can significantly impact their quality of life. Although phytoestrogens offer therapeutic benefits, our understanding of resveratrol's effects remains limited. This study aims to evaluate the effects of using resveratrol on the lipid profile of postmenopausal women. DATA SYNTHESIS: We conducted a systematic review using search terms like "postmenopausal" and "resveratrol" and their synonyms. Two reviewers handled study selection and data extraction. Randomized clinical trials assessing resveratrol in post-menopausal women were included. The meta-analysis on total cholesterol levels found no significant difference between groups, Standardized Mean Difference (SMD) -0.09 (95 % Confidence Interval (CI) -0.39 to 0.22, p = 0.59; I2 = 0 %, 2 studies, low-quality evidence). No significant differences were found in high-density lipoprotein (HDL) levels, SMD 0.00 (95 % CI -0.31 to 0.31, p = 1; I2 = 0 %, 2 studies, low-quality evidence), Low-Density Lipoprotein (LCD) levels, SMD -0.10 (95 % CI -0.40 to 0.21, p = 0.54; I2 = 0 %, 2 studies, low-quality evidence), and triglyceride levels, SMD -0.12 (95 % CI -0.18 to 0.43, p = 0.43; I2 = 0 %, 2 studies, low-quality evidence). CONCLUSION: This review concludes there's limited evidence for recommendations; further studies with higher doses, longer supplementation durations, and exploration of outcomes are needed to clarify therapeutic potential.

Key Findings

This review concludes there's limited evidence for recommendations; further studies with higher doses, longer supplementation durations, and exploration of outcomes are needed to clarify therapeutic potential.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population postmenopausal women
Sample Size 2
Age Range See abstract
Condition See abstract

MeSH Terms

  • Aged
  • Female
  • Humans
  • Middle Aged
  • Age Factors
  • Biomarkers
  • Dyslipidemias
  • Lipids
  • Postmenopause
  • Randomized Controlled Trials as Topic
  • Resveratrol
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09