The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial

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#humans #female #oxidative-stress #postmenopause #resveratrol

The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial

Montoya-Estrada et al., 2024 | Nutrients | Rct

Citation

Montoya-Estrada Araceli, García-Cortés Aline Yunuen, ... Reyes-Muñoz Enrique. The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial. Nutrients. 2024-Nov-03;16(21). doi:10.3390/nu16213775

Abstract

In postmenopausal women, due to endocrine changes, there is an increase in oxidative stress (OS) that predisposes them to cardiovascular and metabolic alterations. Sixty-one percent of women in this stage require a primary therapeutic strategy to decrease OS. This study aimed to evaluate the effect of resveratrol and vitamin C on OS in postmenopausal women. A randomized, double-blind clinical trial was carried out. Forty-six postmenopausal women with insulin resistance (HOMA-IR > 2.5) were included and divided into three treatment groups: group A: resveratrol, n = 13; group B: resveratrol + vitamin C, n = 15; and group C: vitamin C, n = 14. Between before and after the antioxidants, group B showed a decrease of 33% in lipohydroperoxides (p = 0.02), and malondialdehyde (MDA) decreased by 26% (p = 0.0007), 32% (p = 0.0001), and 38% (p = 0.0001) in groups A-C, respectively. For protein damage, group B is the most representative, with a decrease of 39% (p = 0.0001). For total antioxidant capacity (TAC), there were significant increases of 30% and 28% in groups B and C, respectively. For HOMA-IR, there were no significant differences among the study groups. Supplementation with this combination of antioxidants significantly decreases markers of OS in postmenopausal women. In addition, it increases TAC by up to 30%.

Key Findings

In addition, it increases TAC by up to 30%.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population postmenopausal women
Sample Size 13
Age Range See abstract
Condition stress

MeSH Terms

  • Humans
  • Female
  • Oxidative Stress
  • Postmenopause
  • Resveratrol
  • Ascorbic Acid
  • Middle Aged
  • Double-Blind Method
  • Antioxidants
  • Pilot Projects
  • Dietary Supplements
  • Malondialdehyde
  • Insulin Resistance
  • Aged

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: vitamin-c-exercise

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09