S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review

source extracted confidence: high 2026-04-09
#humans #dietary-supplements #liver #liver-diseases #s-adenosylmethionine

S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review

Baden et al., 2024 | Nutrients | Systematic Review

Citation

Baden Kyrie Eleyson R, McClain Halley, ... Chen Aleda M H. S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review. Nutrients. 2024-Oct-28;16(21). doi:10.3390/nu16213668

Abstract

BACKGROUND/OBJECTIVES: S-adenosylmethionine (SAMe) is a natural compound implicated in the treatment of liver dysfunction. In this systematic review, our objective was to determine the efficacy, safety, and optimal dose of SAMe in liver diseases. METHODS: Using the PRISMA methodology, we searched PubMed, CINAHL, and Web of Science using key MeSH search terms. For title/abstract screening, full-text review, and data extraction, two independent researchers reviewed articles, and a third researcher resolved conflicts. Data extraction also included a quality assessment of included articles. RESULTS: Of the 1881 non-duplicated studies, 15 articles focusing on SAMe use in the liver were included. All included studies (n = 15) scored a 4 or 5 out of 5 points on the quality assessment, which indicated high study quality. Overall, SAMe was effective in improving liver-related parameters with few adverse events, which were primarily mild, transient gastrointestinal complaints. CONCLUSIONS: The most common doses were SAMe 1000 mg or 1200 mg per day with or without another treatment or natural supplement. Future studies are needed to assess long-term efficacy and safety data of SAMe and the optimal route of administration in liver diseases.

Key Findings

Of the 1881 non-duplicated studies, 15 articles focusing on SAMe use in the liver were included. All included studies (n = 15) scored a 4 or 5 out of 5 points on the quality assessment, which indicated high study quality. Overall, SAMe was effective in improving liver-related parameters with few adverse events, which were primarily mild, transient gastrointestinal complaints.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 15
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Dietary Supplements
  • Liver
  • Liver Diseases
  • S-Adenosylmethionine

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: same

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09