The effect of Omega-3 supplementation and fish oil on preeclampsia: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#female #humans #pregnancy #dietary-supplements #fatty-acids-omega-3

The effect of Omega-3 supplementation and fish oil on preeclampsia: A systematic review and meta-analysis

Rajati et al., 2024 | Clin Nutr ESPEN | Meta Analysis

Citation

Rajati Mojgan, Rajati Fatemeh, ... Kazeminia Mohsen. The effect of Omega-3 supplementation and fish oil on preeclampsia: A systematic review and meta-analysis. Clin Nutr ESPEN. 2024-Dec;64:274-283. doi:10.1016/j.clnesp.2024.10.146

Abstract

BACKGROUND: Preeclampsia is a type of hypertension disorder characterized by symptoms of damage to other organs. The effect of omega-3 supplementation and fish oil on preeclampsia has been studied several times over the years. Therefore, due to the importance of the subject and the inconsistency of the results of the studies, the present research aimed to estimate the effect of omega-3 supplementation and fish oil on preeclampsia by systematic review and meta-analysis. METHODS: The present systematic review and meta-analysis was performed according to PRISMA guidelines from 1990 to February 2022. A systematic literature review was conducted in MagIran, SID, PubMed, Embase, Scopus, Web of Science (WoS) databases and Google Scholar motor engine using related MeSH/Emtree terms, which were combined with free text word. The heterogeneity of the studies was addressed using I2 index and publication bias was assessed using Egger's regression intercept. RESULTS: The initial systematic literature search retrieved 12095 studies, of which 16 articles with a sample size of 8004 subjects in the intervention group and 8233 in the control group were finally included in the meta-analysis after excluding irrelevant studies. As a result of combining primary studies, the risk ratio of the frequency of total preeclampsia (mild and severe) was obtained (RR: 0.63; 95 % CI, 0.41-0.95, P = 0.027) in the intervention group compared to the control group and risk ratio of the frequency of severe preeclampsia was calculated (RR: 0.45; 95 % CI, 0.24-0.83, P = 0.011) in the intervention group compared to the control group. CONCLUSION: Based on the results of the present study, the consumption of omega-3 supplementation and fish oil significantly reduces the risk of developing preeclampsia. Therefore, it seems that omega-3 supplementation and fish oil can be considered in preventing preeclampsia.

Key Findings

The initial systematic literature search retrieved 12095 studies, of which 16 articles with a sample size of 8004 subjects in the intervention group and 8233 in the control group were finally included in the meta-analysis after excluding irrelevant studies. As a result of combining primary studies, the risk ratio of the frequency of total preeclampsia (mild and severe) was obtained (RR: 0.63; 95 % CI, 0.41-0.95, P = 0.027) in the intervention group compared to the control group and risk ratio of

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 8004
Age Range See abstract
Condition hypertension

MeSH Terms

  • Female
  • Humans
  • Pregnancy
  • Dietary Supplements
  • Fatty Acids, Omega-3
  • Fish Oils
  • Pre-Eclampsia

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09