Efficacy of resveratrol supplementation on lipid profile parameters: An umbrella of meta-analysis

source extracted confidence: high 2026-04-09
#humans #dietary-supplements #lipids #resveratrol #triglycerides

Efficacy of resveratrol supplementation on lipid profile parameters: An umbrella of meta-analysis

Li et al., 2024 | Prostaglandins Other Lipid Mediat | Meta Analysis

Citation

Li Zhe, Liu Sha, ... Li Jian-Long. Efficacy of resveratrol supplementation on lipid profile parameters: An umbrella of meta-analysis. Prostaglandins Other Lipid Mediat. 2024-Dec;175:106903. doi:10.1016/j.prostaglandins.2024.106903

Abstract

Several studies have evaluated the effects of resveratrol supplementation on lipid profile parameters in humans and have demonstrated varying results. We systematically evaluated the literature and performed an umbrella meta-analysis of the effects of resveratrol supplementation on lipid profile. A comprehensive literature search was conducted in the following databases; PubMed, Embase, Scopus, and Web of Science for studies published up to November 2023. According to the standardized mean difference (SMD) analysis, resveratrol supplementation was effective in reducing serum triglyceride (TG) (SMD = -0.14 mg/dl, 95 % CI: -0.24, -0.03; p = 0.001), total cholesterol (TC) (SMD = -0.20, 95 % CI: -0.31, -0.08; p= 0.001), but not high-density lipoprotein cholesterol (HDL-c) (SMD = 0.00, 95 % CI: -0.04, 0.05; p =0.92), and low-density lipoprotein-cholesterol (LDL-c) (SMD = -0.16 mg/dl, 95 % CI: -0.40, 0.07; p =0.17). In the weighted mean difference analysis, resveratrol did not significantly decrease lipid profile parameters. Resveratrol supplementation reduces TC and TG (based on SMD analysis), but it does not significantly affect other indices. However, these significant decreases are not clinically important. Therefore, resveratrol only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.

Key Findings

Therefore, resveratrol only can be considered as an adjunctive therapeutic approach in managing dyslipidemia.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Dietary Supplements
  • Lipids
  • Resveratrol
  • Triglycerides
  • Meta-Analysis as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09