Efficacy and safety of odanacatib in the treatment of postmenopausal women with osteoporosis: a meta-analysis

source extracted confidence: high 2026-04-09
#humans #female #osteoporosis-postmenopausal #bone-density #treatment-outcome

Efficacy and safety of odanacatib in the treatment of postmenopausal women with osteoporosis: a meta-analysis

Li et al., 2024 | J Orthop Surg Res | Meta Analysis

Citation

Li Jiaxuan, Qiu Qi, ... Li Yusheng. Efficacy and safety of odanacatib in the treatment of postmenopausal women with osteoporosis: a meta-analysis. J Orthop Surg Res. 2024-Aug-29;19(1):521. doi:10.1186/s13018-024-05008-z

Abstract

BACKGROUND: Osteoporosis, a systemic skeletal disease, seriously affects the quality of life in postmenopausal women. As one type of cathepsin K (CatK) inhibitor, odanacatib (ODN) is a fresh medication for osteoporosis. Considering the potential of ODN, we further examined the effect and safety of ODN for postmenopausal osteoporosis (PMOP) with a meta-analysis. METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were searched for eligible studies from inception to December 29th, 2023. After that, we conducted a comprehensive meta-analysis following PRISMA guidelines. Risk of bias was meticulously investigated with the Cochrane Collaboration's tool. Efficacy was assessed with bone mineral density (BMD) at different sites (lumbar spine, trochanter, radius, femoral neck) and biomarkers of bone turnover (P1NP, uNTx/Cr, s-CTx, BSAP). Safety was evaluated by analyzing total, serious, other, and skin adverse events (AEs). RESULTS: Four random clinical trials (RCTs) were involved in our research. All trials were rated as having high quality and met the eligibility criteria. In the current research, ODN was found to elevate BMD at lumbar spine, femoral neck, total hip, trochanter and forearm, while it decreased the levels of serum C-telopeptides of type I collagen (s-CTx) as well as urinary N-telopeptide/creatinine ratio (uNTx/Cr). No significant differences were observed in AEs between the ODN group and the control group. CONCLUSIONS: ODN is a promising alternative for the treatment of PMOP on account of its excellent efficacy and credible safety. Unclear links between ODN and cardiovascular AEs require further research to clarify.

Key Findings

Four random clinical trials (RCTs) were involved in our research. All trials were rated as having high quality and met the eligibility criteria. In the current research, ODN was found to elevate BMD at lumbar spine, femoral neck, total hip, trochanter and forearm, while it decreased the levels of serum C-telopeptides of type I collagen (s-CTx) as well as urinary N-telopeptide/creatinine ratio (uNTx/Cr). No significant differences were observed in AEs between the ODN group and the control group.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population postmenopausal women
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Female
  • Osteoporosis, Postmenopausal
  • Bone Density
  • Treatment Outcome
  • Biphenyl Compounds
  • Bone Density Conservation Agents
  • Randomized Controlled Trials as Topic
  • Biomarkers
  • Cathepsin K
  • Middle Aged
  • Aged
  • Bone Remodeling

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09