Effectiveness of vaginal probiotics Lactobacillus crispatus chen-01 in women with high-risk HPV infection: a prospective controlled pilot study

source extracted confidence: high 2026-04-09
#female #humans #probiotics #papillomavirus-infections #pilot-projects

Effectiveness of vaginal probiotics Lactobacillus crispatus chen-01 in women with high-risk HPV infection: a prospective controlled pilot study

Liu et al., 2024 | Aging (Albany NY) | Rct

Citation

Liu Yujuan, Zhao Xiumiao, ... Chen Tingtao. Effectiveness of vaginal probiotics Lactobacillus crispatus chen-01 in women with high-risk HPV infection: a prospective controlled pilot study. Aging (Albany NY). 2024-Jul-25;16(14):11446-11459. doi:10.18632/aging.206032

Abstract

Female genital tract infection with high-risk human papilloma virus (HR-HPV) has the risk of developing into cervical cancer, and there is still a lack of effective therapeutic strategies. Probiotic intervention is considered as a potential intervention for HR-HPV, while exploration into living probiotic preparations for specific diseases remains limited and insufficient. This prospective controlled pilot study was conducted to observe the effect of intravaginal transplantation of a vaginal isolated natural probiotic strain, Lactobacillus crispatus chen-01, on the clearance of high-risk HPV infection. 100 women with high-risk HPV infection were enrolled and randomly divided into placebo group and probiotic treatment group, which received intravaginal transplantation of L. crispatus chen-01. Cervical exfoliated cells were collected 6 months later for detecting DNA load, typing of HPV, and cytological analysis. Our results showed that vaginal transplantation with L. crispatus chen-01 significantly reduced viral load of HPV, ameliorated HPV clearance rate, and improved vaginal inflammation state without causing obvious adverse reactions. Analysis of 16S rRNA sequencing revealed that L. crispatus chen-01 could effectively reconstitute the vaginal microbiota in women with high-risk HPV, which might be one of the underlying mechanisms of the beneficial effect of L. crispatus chen-01 transplantation. Our results suggested that vaginal transplantation of L. crispatus chen-01 might be a promising treatment for patients with high-risk HPV infection.

Key Findings

crispatus chen-01 might be a promising treatment for patients with high-risk HPV infection.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population high
Sample Size See abstract
Age Range See abstract
Condition inflammation

MeSH Terms

  • Female
  • Humans
  • Probiotics
  • Papillomavirus Infections
  • Pilot Projects
  • Lactobacillus crispatus
  • Vagina
  • Adult
  • Prospective Studies
  • Administration, Intravaginal
  • Viral Load
  • Middle Aged
  • Papillomaviridae
  • Microbiota

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: probiotics-immune

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09