Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#humans #exercise-tolerance #heart-failure #stroke-volume #treatment-outcome

Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis

Qazi et al., 2024 | Future Cardiol | Meta Analysis

Citation

Qazi Shurjeel Uddin, Bin Naeem Muhammad Ahrar, ... Mattumpuram Jishanth. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024-Mar-11;20(4):221-228. doi:10.1080/14796678.2024.2352308

Abstract

Aim: We aim to analyze past literature to evaluate the efficacy of coenzyme Q10 (CoQ-10) in the population with heart failure (HF). Methods: A systematic literature search was conducted through MEDLINE (via PubMed) and Cochrane Library. The outcomes analyzed were a reduction in HF-related mortality, an improvement in exercise capacity, and the left ventricular ejection fraction (LVEF). Results: Among 16 studies, CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity in patients with HF, but demonstrated no significant difference in LVEF however, the potential of its efficacy on LVEF could not be ruled out. Conclusion: CoQ-10 significantly enhances exercise capacity and reduces HF-related mortality; however, its impact on patients with reduced LVEF requires further investigation.

Key Findings

Among 16 studies, CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity in patients with HF, but demonstrated no significant difference in LVEF however, the potential of its efficacy on LVEF could not be ruled out. Conclusion: CoQ-10 significantly enhances exercise capacity and reduces HF-related mortality; however, its impact on patients with reduced LVEF requires further investigation.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population hf
Sample Size 16
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Exercise Tolerance
  • Heart Failure
  • Stroke Volume
  • Treatment Outcome
  • Ubiquinone
  • Ventricular Function, Left

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: coq10-heart

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09